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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

There are two studies available addressing skin sensitisation of C12-14AS Na (CAS 85586-07-8).

The skin sensitizing potential of C12-14AS Na (CAS 85586-07-8, analytical purity 29.9%) was assessed in a Guinea Pig Maximisation Test similar to OECD Guideline 406 (Unilever, 1977). In this study 10 guinea pigs were induced by intradermal and occlusive epicutaneous application of the test item at concentrations of 0.08% (intradermal induction) and 0.5% (epicutaneous induction). Challenge and re-challenge was performed with 0.1%. Water was used as vehicle. None of the treated animals showed a positive reaction after challenge. Thus, the test item showed no significant sensitising potential within this study.

Another study with C12-14AS Na (CAS 85586-07-8) was performed with 10 guinea pigs following no special guideline (Brown, 1970). 0.1% of the test substance was applied topical or intradermal on 3 days/week for 3 weeks. 10 days after induction animals were challenged with an unknown concentration of test substance. Skin reactions were scored 1, 24 and 48 h after challenge. The only findings were very slight skin reactions in 3/10 animals 24 h after intradermal application. No skin reaction was observed after topical application.

Results of the above mentioned studies show that C12-14AS Na (CAS 85586-07-8) showed no skin sensitising properties. In addition the structural related substance sodium lauryl sulphate (C12AS Na) is also recommended as an agent to induce local irritation in an OECD method to assess skin sensitising properties of chemicals (OECD guideline 406, Guinea Pig Maximisation Test). Therefore there is a lot of experience with sodium lauryl sulfate in sensitising studies and no evidence occurred that it shows sensitising properties. Thus, skin sensitisation by members of the alkyl sulfates is generally unlikely.


Migrated from Short description of key information:
Skin sensitisation (GPMT - OECD 406): not sensitising

Justification for selection of skin sensitisation endpoint:
Both studies are performed according to OECD guideline 406 with a negative outcome. Therefore no study was chosen.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

The available data on skin sensitisation do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification. No data available for respiratory sensitisation.