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Description of key information

No experimental toxicokinetic study is available on 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolisation and excretion may be deduced from the physicochemical properties. 
Oral absorption could be observed at high concentrations, but a low absorption of 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid after dermal or inhalation exposure is expected.

Key value for chemical safety assessment

Additional information

No experimental toxicokinetic study is available on 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolisation and excretion may be deduced from the physicochemical properties, including:

-Range of molecular weight: 488 -630 g/mol

-Water solubility: 1.38 mg/L (20°C)

-Partition coefficient Log Kow: 1.73-3.11

-Vapour pressure: 0,0000667 Pa

 

ABSORPTION

The value of log Kow (between 1.7 and 3.11) is in the range suggestive of favourable absorption from the gastro-intestinal tract subsequent to oral ingestion, despite a low water solubility. This assumption of an oral absorption is confirmed in the acute toxicity studies: systemic effects (e.g. piloerection) were observed in rats treated at 2000 mg/kg bw, and mortalities occurred at the dose of 5000 mg/kg bw. Indeed, 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid can be absorbed by oral route at the high doses.

Log Kow between 2 and 3 is are optimal to have a good dermal absorption, however the low solubility can limit this absorption. Moreover, the acrylates are known to bind to skin components, and this binding decreases their dermal absorption. Experimental data suggest a low dermal absorption. In the dermal acute toxicity study, no systemic effect or mortality was observed in rats treated at 2000 mg/kg bw. And an analoguous substance of 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid showed no allergic reaction in the GMPT (skin sensitisation test on guinea pigs).

Based on the low value of the vapour pressure, 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid is not a volatile substance. Based on the low values of vapour pressure and water solubility, no absorption by inhalation is expected for this substance.

 

DISTRIBUTION and METABOLISM

The molecule is lipophilic (log Kow between 1.7 and 3.11), it is likely to distribute into cells and the intracellular concentration may be higher than extracellular concentration particularly in fatty tissues.

No specific data is available on the metabolism of 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid.

 

ELIMINATION

Due to the low water solubility and a moderate molecular mass (between 200 and 1000 g/mol),the excretion of 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid in the urines is not expected. An excretion via bile and faeces is possible.