Registration Dossier
Registration Dossier
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EC number: 231-842-9 | CAS number: 7758-89-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Already evaluated by the Competent Authorities for Biocides and Existing Substance Regulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: BASF-Test
- Principles of method if other than guideline:
- Several groups of 10 to 20 rats/group were treated by gavage with suspensions of the test substance in 0.5% Carboxylmethyl cellulose (CMC) aqueous preparation. Group-wise documentation of clinical signs was performed over the 14-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Copper chloride
- EC Number:
- 231-842-9
- EC Name:
- Copper chloride
- Cas Number:
- 7758-89-6
- Molecular formula:
- ClCu
- IUPAC Name:
- λ¹-copper(1+) chloride
- Details on test material:
- Analytical purity: 98 - 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males 243g, females 166g (mean)
- Diet: Herilan (Heinrich Eggersmann, Rinte)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1.47 - 4.64% suspension in 0.5% aqueous CMC preparation
- Doses:
- 147, 215, 316, 383 and 464 mg/kg bw
- No. of animals per sex per dose:
- 5 and 10 respectively
- Control animals:
- no
- Statistics:
- Probit analysis
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 336 mg/kg bw
- 95% CL:
- 279 - 487
- Mortality:
- LD50 = approx. 336 mg/kg bw.
3 male and 4 female rats of the 464 mg/kg bw dose group, 4 male and 4 female rats of the 383 mg/kg bw dose group died within 2 and 7 days respectively after administration. - Clinical signs:
- other: Signs of toxicity noted in the 215, 261, 316, 384 and 464 mg/kg bw dose groups comprised apathy, poor general state and diarrhoea.
- Gross pathology:
- Heart: dilation, acute congestive hyperemia
Stomach: scabbed corrosion and bloody ulcerations in glandular stomach (corrosive gastritis)
Intestine: atonic, diarrheic content
Any other information on results incl. tables
Dose (mg/kg bw) |
Mortality Dead/Treated |
|||||||||
1 hour |
24 hours |
48 hours |
7 days |
14days |
||||||
male |
female |
male |
female |
male |
female |
male |
female |
male |
female |
|
147 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
1/5 |
0/5 |
1/5 |
215 |
0/10 |
0/10 |
0/10 |
3/10 |
1/10 |
3/10 |
1/10 |
6/10 |
1/10 |
6/10 |
261 |
0/5 |
0/5 |
1/5 |
1/5 |
1/5 |
1/5 |
2/5 |
1/5 |
2/5 |
1/5 |
316 |
0/10 |
0/10 |
3/10 |
1/10 |
3/10 |
1/10 |
3/10 |
1/10 |
3/10 |
1/10 |
383 |
0/5 |
0/5 |
1/5 |
2/5 |
1/5 |
3/5 |
4/5 |
4/5 |
4/5 |
4/5 |
464 |
0/5 |
0/5 |
3/5 |
4/5 |
3/5 |
4/5 |
4/5 |
4/5 |
4/5 |
4/5 |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
Copper chloride is harmful
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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