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Long-term toxicity to aquatic invertebrates

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No chronic toxicity studies have been carried out on aquatic invertebrates with registration substance. Composition information, derived using two dimensional gas chromatography, has been used in conjunction with the PETROTOX model v 3.06 to calculate this endpoint.

 

The aquatic toxicity was estimated using the PETROTOX computer model, which combines a partitioning model (used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading) with the Target Lipid Model (used to calculate acute and chronic toxicity of non-polar narcotic chemicals). PETROTOX computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a petroleum substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.

The model predicted a chronic EL10 of the substance to aquatic invertebrates to be 0.54 mg/L.

 

QSAR predictions on long term toxicity to aquatic invertebrates of VHGO have also been provided to support the read-across from VHGO to registration substance.