Registration Dossier

Administrative data

Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was conducted according to the O.E.C.D. test guideline with GLP compliance.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report Date:
2012

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
not specified
GLP compliance:
yes
Type of method:
HPLC estimation method
Media:
other: HPLC column

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
As per IUCLID Sections 1.1. 1.2. and 4.1.
Radiolabelling:
no

Study design

Test temperature:
Ambient

HPLC method

Details on study design: HPLC method:
Approximately 0.14 gram of the test substance was plased in a 10 ml volumetric and brough up to volume with methanol. Acalibration curve using structurally related reference compounds with known Log koc was established. The test substance and reference compounds with known Log Koc values were injected into an HPLC system. A calibration cruve using retention time (Log t) verses Log koc was calculated by linear regression analysis from the injection data of the reference compounds. The calibration was calculated from the literature values for the Log koc for the reference compoundsand the corresponding capacity factor. From the calibration cruve the unknown Log Koc of the test substance was estimated by retention observed under similar HPLC operational conditions.

Batch equilibrium or other method

Analytical monitoring:
yes

Results and discussion

Adsorption coefficient
Type:
Koc
Value:
ca. 425
Remarks on result:
other: Study was conducted a room temperature including HPLC column.

Results: HPLC method

Details on results (HPLC method):
Test substance Koc = 425 and the Log Koc = 2.63 based on estimation from the HPLC calibration curve retentions.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Test substance Koc = 425 based on the HPLC method.
Executive summary:

The test substance, :4,4'-Isopropylidenedicyclohexanol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, was determined to have a Koc of 425 (Log Koc = 2.63) based on the HPLC method.