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EC number: 203-398-6 | CAS number: 106-44-5
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: special study and only one dose used, no dose-response relationship can be derived and thus no NOAEL or LOAEL can be deduced.
Data source
Reference
- Reference Type:
- publication
- Title:
- p-Cresol: cause of ink-induced hair depigmentation in mice
- Author:
- Shelley WB
- Year:
- 1 974
- Bibliographic source:
- British Journal of Dermatology 90, 9-174 (1974)
Materials and methods
- Principles of method if other than guideline:
- Hair pigmentation was studied following plucking or clipping the caudal half of the back and repeated application of laundry ink or its pure component chemicals incl. p-cresol in a concentration of 0.5% in acetone.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- p-cresol
- EC Number:
- 203-398-6
- EC Name:
- p-cresol
- Cas Number:
- 106-44-5
- Molecular formula:
- C7H8O
- IUPAC Name:
- p-cresol
- Details on test material:
- Test substance: p-cresol, purity not noted
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 6 weeks
- Frequency of treatment:
- 3x/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0 or 0.5 % in acetone
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Post-exposure period: 6 months
Results and discussion
Results of examinations
- Details on results:
- migrated dataset
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- < 0.5
- Sex:
- female
- Dose descriptor:
- LOAEL
- Effect level:
- <= 0.5
- Sex:
- female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Applicant's summary and conclusion
- Executive summary:
p-Cresol was applied to the skin of five female Agouti mice three times weekly for 6 weeks. Hair colour was observed weekly for the subsequent 6 months. Microscopic examinations of post-treatment hairs and skin biopsies of areas of non-pigmented and normally pigmented hair were made. Control groups of animals received acetone.
No hair depigmentation and no microscopic changes were noted.
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