Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Effects of phenolic smoke condensates and their components on hepatic drug metabolizing systems
Author:
Sternitzke A, Legrum W, Netter KJ
Year:
1992
Bibliographic source:
Fd Chem Toxic 30, 771-781
Reference Type:
publication
Title:
Ueber die Wirkung der Cresole und des Liquor Cresoli Saponatus im Vergleich zur Carbolsaeure
Author:
Tollens K
Year:
1905
Bibliographic source:
Arch Exp Path Pharm 52, 220-241

Materials and methods

Principles of method if other than guideline:
other
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
p-cresol
EC Number:
203-398-6
EC Name:
p-cresol
Cas Number:
106-44-5
Molecular formula:
C7H8O
IUPAC Name:
p-cresol
Details on test material:
Test substance: p-cresol, no further data

Test animals

Species:
mouse

Administration / exposure

Route of administration:
subcutaneous

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
150 mg/kg bw

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Executive summary:

Mice received a single subcutaneous injection of p-cresol. A LD50 = 150 mg/kg bw was determined.