Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-398-6 | CAS number: 106-44-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Regarding all available test on toxicity to microorganisms, the most relevant test resulting in the lowest PNEC value is used for assessment.
The sensitivity of activated sludge to p-cresol was determined by a respiration inhibition test according to OECD Guideline 209. The 2h IC50 for respiration inhibion of microorganisms is 440 mg/L.
The effect of p-cresol on Nitrosomonas activity was measured as a nitrification inhibition method comparable to ISO/DIS 9509. The 24 h-IC50 was 27 mg/L.
For respiration, the 49 h-IC50 was 260 mg/L. Nitrification inhibition by p-cresol was also measured by a similar method yielding an EC75 of 16.5 mg/L during a 2 -4 h incubation period. The EC50(48 h) with respect to growth of Tetrahymena pyriformis accounts for 157 mg/L testing p-cresol.
In order to protect the efficiency of sewage treatment plants, inhibition of nitrification is identified to be the most sensitive test system.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 16.5 mg/L
Additional information
Several tests are available to evaluate the toxicity of p-cresol to microorganisms.
The influence of p-cresol on the nitrification process in domestic wastewater is described in an experiment. A purified activated sludge was incubated for 2 to 4 hours to the wastewater (BSB5 = 250 mg/l, 50 to 80 mg NH4-N/l) fortified with different concentrations of p-cresol. The effect on the inhibition of the nitrification was determined by photometric analysis of nitrite and nitrate. An EC75-value of 16.5 mg/l is given for the inhibition of the reaction step of ammonia to nitrite. Nitrification inhibition by p-cresol was also measured by a similar method yielding an IC50 of 27 mg/L during a 2 h incubation period.
The protozoa Tetrahymena pyriformis was exposed to p-cresol for 48 hours using the cell multiplication inhibition test method. An EC50 of 157 mg/l was obtained.
The sensitivity of activated sludge to p-cresol was determined by a respiration inhibition test according to OECD Guideline 209. The 3h IC50 for respiration inhibion of microorganisms is 440 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.