Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: limited reported study

Data source

Reference
Reference Type:
publication
Title:
Ethers in Anaesthesia
Author:
Amiot LG
Year:
1932
Bibliographic source:
Presse Med. 40:300-302

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl ether
EC Number:
204-065-8
EC Name:
Dimethyl ether
Cas Number:
115-10-6
Molecular formula:
C2H6O
IUPAC Name:
dimethyl ether

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intraperitoneal
Doses:
5 mg/kg

Results and discussion

Applicant's summary and conclusion

Conclusions:
The test substance is less efficient than diethylether as an anesthetic in animals. It does however have both vasodilator and hypotensor effects. Intraperitoneal doses of 5 mg/kg DME produced reversible anethesia in mice.