Registration Dossier
Registration Dossier
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EC number: 204-065-8 | CAS number: 115-10-6
Endpoint summary
Administrative data
Description of key information
4h-LC50 = 164000 ppm (309018 mg/m3); 4 -h LOAEL = 84000 ppm (158277 mg/m3)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 309 018 mg/m³ air
- Physical form:
- inhalation: gas
- Quality of whole database:
- Available data show consistent results; conclusions fulfil the quality criteria (validity, reliability, repeatability).
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Predominant acute effect of inhalational exposure to high concentrations of DME is anaesthesia. Narcotic effects have been reported in humans at an atmospheric concentration of 120000 ppm.
The substance has low inhalation toxicity (lethality) with a rat 4-hour LC50 value of 164000 ppm. During inhalation to concentrations of 84000 ppm acute toxicity was observed in the form of ataxia, anaesthesia in 2 hours, short jerky respirations and lung noise (post exposure).During inhalation to ≥ 121000 ppm acute toxicity was observed in the form of ataxia, anaesthesia in 15 -30 minutes, heavy respiration, coma and lung noise (post exposure).
This substance is a gas, and tests to evaluate dermal and oral systemic toxicity are technically not feasible.
Justification for classification or non-classification
Based on the rat 4-hour LC50 of 164000 ppm (309018 mg/m3), anesthetic and clinical effects after 2 hours of exposure to 84000 ppm (158277 mg/m3), and the minimal startle response effects at 20000 ppm (37685 mg/m3) in the developmental study, the substance does not need to be classified for acute toxicity according the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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