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Description of key information

Rapidly absorbed and distributed following exposure by inhalation. No bioaccumulation potential.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - inhalation (%):
100

Additional information

DME is a volatile substance and potential exposure would likely occur via the inhalation route. Therefore, no worker oral or dermal route absorptions are indicated.

The toxicokinetics of DME in rats were evaluated following 1 hour inhalation of 1000 ppm (1.9 mg/L) and 30 minutes to concentrations between 745 and 2000 ppm (between 1.4 and 3.8 mg/L) DME. Test substance concentrations were determined in rat blood, heart, lungs, liver, spleen, kidneys, fat, muscles and brain. The test substance was absorbed into blood and distributed widely to organs and tissues. The increases in test substance concentrations in these organs/tissues, including brain, were rapid and similar except for a slower increase in fat and muscles. Test substance concentrations in fat were approximately 30% higher than in other tissues. After a 1-hour exposure to 1000 ppm, test substance levels decreased rapidly and equally (except for fat which was cleared slightly slower). Following a single short spraying application in humans, test substance concentrations in blood were low and decreased rapidly following the exposure.

It is concluded that the test substance is rapidly absorbed into the blood and tissues, is quickly eliminated once the exposure is terminated, and has a low bioaccumulation potential in rats and humans.