Registration Dossier
Registration Dossier
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EC number: 203-473-3 | CAS number: 107-21-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Evaluation of the Developmental Toxicity of Ethylene Glycol Aerosol in the CD Rat and CD-1 Mouse by Whole-Body Exposure.
- Author:
- Tyl RW, Ballantyne B, Fisher LC, Fait DL, Savine TA, Dodd DE, Klonne DR, Pritts IM
- Year:
- 1 995
- Bibliographic source:
- Fundamental and Applied Toxicology 24: 57-75
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
- Principles of method if other than guideline:
- LC50 value derived from teratogenicity study.
- GLP compliance:
- yes
- Test type:
- other: LC50 value derived from teratogenicity study
- Limit test:
- no
Test material
- Reference substance name:
- Ethane-1,2-diol
- EC Number:
- 203-473-3
- EC Name:
- Ethane-1,2-diol
- Cas Number:
- 107-21-1
- Molecular formula:
- C2H6O2
- IUPAC Name:
- ethane-1,2-diol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- see 7.8.2 Developmental toxicity / teratogenicity
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Details on inhalation exposure:
- see 7.8.2 Developmental toxicity / teratogenicity
- Duration of exposure:
- 6 h
- Concentrations:
- 60, 400 or 1000 ppm
150, 1000 or 2500 mg/m3 (0.15, 1.00 or 2.5 mg/L) - No. of animals per sex per dose:
- see 7.8.2 Developmental toxicity / teratogenicity
- Control animals:
- yes
- Details on study design:
- see 7.8.2 Developmental toxicity / teratogenicity
- Statistics:
- see 7.8.2 Developmental toxicity / teratogenicity
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.5 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 6 h
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
