Registration Dossier
Registration Dossier
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EC number: 203-473-3 | CAS number: 107-21-1
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
From the available test data in combination with the QSAR calculation it can be concluded, that the substance shows a very low long-term toxicity to aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 8 590 mg/L
Additional information
Data on long-term effects to aquatic invertebrates are available for ethylene glycol ([Pillard, 1995).
The study with ethylene glycol was conducted according to EPA guideline 600/4-89/001 with Ceriodaphnia dubia as test specie. This test was terminated when 60% of the control organisms had produced three broods. After a test duration of 7 days the NOEC for reproduction was determined to be 8590 mg/L for ethylene glycol (nominal, Pillard, 1995).
No analytical monitoring was performed during the test study; however, the test substance is expected to be stable in water based on its physicochemical properties:
The Substance has a sufficiently high water solubility (miscible, cited in HSDB Database, see IUCLID Ch. 4.8). Adsorption is not expected based on the low log Kow (-1.36, cited in HSDB Database, see IUCLID Ch. 4.7) and log Koc (log Koc = -1.03; estimated; EPI Suite v4.11, KOCWIN v2.00, BASF SE, 2021). The Substance is not expected to evaporate from the test solution based on its low Henry's Law Constant (HLC = 0.1327 Pa m³/mol, 25 °C, estimated; EPI Suite v4.11, HENRYWIN v3.20; in applicability domain; BASF SE, 2021) and its low vapor pressure (VP = 0.123 hPa, cited in HSDB Database, see IUCLID Ch. 4.6).
Additionaly, for the test substance the long-term toxicity to aquatic invertebrates was determined using a valid QSAR model (ECOSAR v2.0; BASF SE, 2022). The ChV for the test substance was predicted to be 909 mg/L. The substance is within the applicability domain of the model.
Overall, experimental and estimated chronic values are clearly greater than 1 mg/L with regard to classification limits and also greater than 10 mg/L, which the limit concentration in long-term toxicity testing; therefore, long-term effects on aquatic invertebrates are not to be expected.
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