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EC number: 203-473-3 | CAS number: 107-21-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability the test substance is acutely not harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 53 000 mg/L
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 72 860 mg/L
Additional information
Experimental data are available to determine acute toxicity of ethylene glycol to fish.
A short-term study using Pimephales promelas was performed. The 96 -h LC50 value was measured to be beyond 72860 mg/L [Pillard, 1995]. Additionally, the study performed by Mayes M. A. et al (1983) is also available. The short-term tests were performed with the fry, juveniles and subadult of Pimephales promelas. The geometric meam value for all determined endpoints is 53000 mg/L (nominal).
Theese results are supported with the estimated value, wich was derived from a valid QSAR model (ECOSAR v2.0; BASF SE, 2022). The 96 -h LC50 for the substance was predicted to be 53099 mg/L. The substance is within the applicability domain of the model.
No analytical monitoring was performed during the test stuies; however, the test substance is expected to be stable in water based on its physicochemical properties:
The Substance has a sufficiently high water solubility (miscible, cited in HSDB Database, see IUCLID Ch. 4.8). Adsorption is not expected based on the low log Kow (-1.36, cited in HSDB Database, see IUCLID Ch. 4.7) and log Koc (log Koc = -1.03; estimated; EPI Suite v4.11, KOCWIN v2.00, BASF SE, 2021). The Substance is not expected to evaporate from the test solution based on its low Henry's Law Constant (HLC = 0.1327 Pa m³/mol, 25 °C, estimated; EPI Suite v4.11, HENRYWIN v3.20; in applicability domain; BASF SE, 2021) and its low vapor pressure (VP = 0.123 hPa, cited in HSDB Database, see IUCLID Ch. 4.6).
Overall, it can be concluded that based on the available experimental and estimated data the substance is with high probability acutely not harmful to fish.
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