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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2015
Reliability:
other: significant variance in dose and humidity
Rationale for reliability incl. deficiencies:
other: significant variance in dose and humidity, only evaluation of study base on raw data possible

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report Date:
2015

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
Deviations:
yes
Principles of method if other than guideline:
significant variance in dose and humidity
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: dust

Test animals

Species:
rat
Strain:
other: RccHan™:WIST rat.
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
nose only
Vehicle:
clean air
Remarks on MMAD:
MMAD / GSD: see rwa data
Analytical verification of doses or concentrations:
yes
Duration of treatment / exposure:
see rwa data
Frequency of treatment:
see rwa data
Doses / concentrations
Remarks:
Doses / Concentrations:
see rwa data
Basis:
other: see rwa data
No. of animals per sex per dose:
see rwa data
Control animals:
yes

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion