Tin sulphate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

endpoint for information only

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Report date:

2012

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)

Deviations:

no

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

stannous oxalate

IUPAC Name:

stannous oxalate

Test animals

Species:

rat

Strain:

other: HsdHan:WIST strain

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

nose only

Vehicle:

air

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

4 h

Concentrations:

5, 1, 0.5 mg/L

No. of animals per sex per dose:

6

Control animals:

no

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

2 mg/L air

Based on:

test mat.

Remarks:

dust

Exp. duration:

4 h

Remarks on result:

other: calculated LC50 in accordance with OECD 436

Effect levels 2

Sex:

male/female

Dose descriptor:

LC0

Effect level:

0.5 mg/L air

Based on:

test mat.

Remarks:

dust

Exp. duration:

4 h

Remarks on result:

other: at the dose of 0.5 mg/L no mortality was observed

Remarks:

.

Mortality:

All animals treated at a concentration of 5 mg/L died or were killed in extremis. Two males and one female treated at a concentration of 1 mg/L died or were killed in extremis. All animals exposed to a concentration of 0.5 mg/L survived treatment.

Body weight:

All surviving rats showed a loss in body weight during the first week of the observation period. However, all surviving rats gained weight during the second week of the observation period. All surviving rats, except for two females exposed to a concentration of 1 mg/L had reached their pre-exposure body weight by Day 15.

Gross pathology:

Abnormalities noted at necropsy of animals that that died or were killed in extremis during the study were red, dark, mottled or inflated lungs, pale or dark areas on the lungs, gaseous distension of the stomach, red nasal cavity, white substance in the nasal cavity and small and red thymus. No abnormalities were noted at necropsy of animals killed at the end of the study period except for pale or dark foci on the lungs noted in one female treated at a concentration of 0.5 mg/L.

Applicant's summary and conclusion

Interpretation of results:

other: Category 4 based on EU GHS criteria

Conclusions:

The test material was classified as Category 4 in respect of its acute inhalation toxicity according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).