Registration Dossier

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Administrative data

Description of key information

The carcinogenicity of sodium percarbonate is expected to depend on the hydrogen peroxide released in aquatic media.

Key value for chemical safety assessment

Justification for classification or non-classification

The read-across approach taken in the OECD SIDS dossier is followed to conclude on the carcinogenicity of sodium percarbonate. The following text is copied from the OECD SIDS dossier, section 3.1.7, page 20 (OECD 2006):

"Carcinogenicity studies with animals and sodium percarbonate are not available. The only component that could give rise to some concerns with regard to this endpoint is hydrogen peroxide. A local carcinogenic effect was observed in the duodenum of a catalase-deficient mouse strain administered 0.4 % hydrogen peroxide in drinking water. Although an underlying genotoxic mechanism cannot be excluded, the weight of evidence at this time does not suggest that the carcinogenic properties of hydrogen peroxide should be regarded as practically significant."

Additional information

The carcinogenic potential of sodium percarbonate has not been tested. In the OECD SIDS dossier for sodium percarbonate (OECD 2006) a read-across approach is chosen to close this data gap. In the dossier any carcinogenic potential would be attributed to the hydrogen peroxide released during the dissociation of sodium percarbonate. Thus, an available drinking water study on the carcinogenicity of hydrogen peroxide in catalase-deficient mice was used to conclude that the carcinogenic potential of sodium percarbonate is practically insignificant (OECD 2006).