Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Additional information:

The skin sensitisation potential of sodium percarbonate was tested in male and female guinea pigs (Glaza 1990e) according to the Health Effects Test Guideline of the U.S. EPA Office of Pesticides and Toxic Substances (August 1982) and following the conditions of GLP. Very faint to faint dermal reactions were elicited from all ten test animals during the induction phase. None of the test or naive control animals reacted to the challenge application of the test material. All four animals in the positive control group reacted during the induction and challenge phases of the study. The positive control animals were considered to be sensitised because of the strong reactions they exhibited to the 0.1 % w/v concentration of DNCB in acetone. Based upon the results, sodium percarbonate is not considered as a skin sensitizer in guinea pigs.


Migrated from Short description of key information:
A valid study on skin sensitisation carried out with guinea pigs (maximisation test, Glaza 1990e) shows that sodium percarbonate is not sensitising to the skin.

Justification for classification or non-classification

Based on experience from manufacture and use of sodium percarbonate the substance has no skin sensitising properties in humans. In addition, the dissociation products of sodium percarbonate, hydrogen peroxide and sodium carbonate, have no sensitising properties (European Commission 2003, OECD 2002).

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