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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

additional toxicological information
Type of information:
other: review
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: JECFA Monograph

Data source

Reference Type:
Safety evaluation of certain food additives and contaminants – esters of aliphatic acyclic primary alcohols with aliphatic linear saturated carboxylic acids.
Bibliographic source:
WHO FOOD ADDITIVES SERIES 40, The forty-ninth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Materials and methods

Type of study / information:
Summary of Evaluations Performed by the Joint FAO/WHO Expert Committee on Food Additives

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl octanoate
EC Number:
EC Name:
Methyl octanoate
Cas Number:
Molecular formula:
methyl octanoate
Details on test material:
- Name of test material (as cited in study report): methyl octanoate
- Analytical purity: no data
- Other: Functional class: flavouring agent

Results and discussion

Any other information on results incl. tables

Intake estimates (Europe): 9.7 µg / person per day

Latest evaluation: 1997


Comments: No safety concern at current levels of intake when used as a flavouring agent

Report: TRS 884-JECFA 49/52

Specifications: COMPENDIUM ADDENDUM 5/FNP 52 Add.5/224

Tox monograph: FAS 40-JECFA 49/297

Estimated daily per capita intake

The total annual volume of the 67 esters in this group is approximately 19 tonnes in the USA and 65 tonnes in Europe. In the USA

more than 70% of the total annual volume is accounted for by five substances, amyl butyrate, cis-3- & trans-2-hexenyl propionate,

and the acetate esters of propyl alcohol, isobutyl alcohol and 2-methylbutyl alcohol.

In Europe, more than 75% of the total annual volume is accounted for by seven substances, butyl butyrate, amyl butyrate and the acetate esters of methyl alcohol, butyl alcohol, hexyl alcohol, cis-3-hexenol and isobutyl alcohol. Based on the reported annual volumes in the USA and Europe, the total estimated daily per capita intake of the 67 esters of aliphatic acyclic primary alcohols and aliphatic linear saturated carboxylic acids used as flavouring agents is 3.8 mg per capita per day in the USA and 9.2 mg per capita per day in Europe. The use of 7 of the esters (heptyl formate, octyl propionate, decyl propionate, decyl butyrate, butyl heptanoate, butyl dodecanoate, cis-3- & trans-2-hexenyl propionate) has been reported in the USA but not in Europe.

Esters of aliphatic acyclic primary alcohols and aliphatic linear saturated carboxylic acids are principal components of alcoholic

beverages and a wide variety of fruits. Quantitative data on the natural occurrence in food have been reported for 37 substances in the

group. In the USA, it is indicated that intake of these substances from natural sources exceeds intake from their use as flavouring agents.

Applicant's summary and conclusion