Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-835-0 | CAS number: 111-11-5
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 78% in 28 days (OECD 301C, Modified MITI Test)
Key value for chemical safety assessment
Additional information
No experimental data evaluating the biodegradation potential of methyl octanoate (CAS No. 111-11-5) are available. Therefore, biodegradation data from a structurally related category member, methyl laurate (CAS No. 111-82-0) are used as read-across in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Both methyl octanoate and methyl laurate are fatty acid esters esterified with methanol, differing only on the length of the fatty acid C-chain (C8 and C12 respectively). Since the potential for biodegradation is expected to decrease at increasing C-chain lengths, read-across from methyl laurate to methyl octanoate will represent a worst-case scenario for this substance (the biodegradation of C8 will probably be underestimated). Nevertheless, based on the structural similarities between both substances this read-across possibility is justified.
One study evaluating the biodegradation potential of methyl laurate (CAS No. 111-82-0) is available (Japanese Ministry of Economy, Trade and Industry, 1995). In this GLP-study, conducted according to OECD 301C, a mixture of sewage, soil and natural water was used as inoculum and O2 consumption monitored as indicator of biodegradation. After 28 days of incubation, the test substance reached 78% biodegradation. Since the 10-day window concept does not apply to the MITI method, methyl laurate is readily biodegradable according to OECD criteria.
Based on the results obtained for a structurally related category member (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5) methyl octanoate can be considered as readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
