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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2nd March 2010 to 12 March 2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The method is not strictly adapted to the study of glasses, which are only loosely speaking polymers being 3 dimensional polymeric siicates, which fail in aqueous environments and do not dissolve nor release extractable materials.
Qualifier:
according to guideline
Guideline:
other: OECD 120
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
ca. 0.35 mg/L
Temp.:
20 °C
pH:
ca. 7
Conclusions:
Interpretation of results: slightly soluble (0.1-100 mg/L)
the solubility of this substance is less than 1mg/l when tested under the test conditions described above
Executive summary:

The substance under consideration in this dossier does not strictly speaking dissolve in water, some material may be leached from the glass structure. Any gravimetric estimation of weight loss in water is complicated by fibres being retained at the meniscus by surface tension effect and adherence to any glass surface, so that recovery rarely exceeds 90%.

see SW fact sheets for statement on leaching ions.

Description of key information

The water solubility of this substance is less than 1mg/l and as such for the purposes of REACH can be considered insoluble.

Key value for chemical safety assessment

Water solubility:
0.35 mg/L
at the temperature of:
20 °C

Additional information

The substance under consideration in this dossier does not strictly speaking dissolve in water, some material may be leached from the glass structure. Any gravimetric estimation of weight loss in water is complicated by fibres being retained at the meniscus by surface tension effect and adherence to any glass surface, so that recovery rarely exceeds 90%.

Fibres of this type are sometimes described as bio-soluble as they clear rapidly from the lung. Rather they break and the fragments are cleared by the normal physiological method (Moore M, Brown R.C., Pigott G, 2001, Material Properties of MMVF and their time dependant failure in lung environments, Inhalation Toxicology, Vol. 11, pages 1117 - 1149). Thus the description as bio-soluble is erroneous and only used to distinguish these fibres from those that resist lung clearance.

Any materials leaching from the fibres are ubiquitous and non-toxic,