Registration Dossier
Registration Dossier
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EC number: 203-313-2 | CAS number: 105-60-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
Data source
Reference
- Reference Type:
- publication
- Title:
- About the pharmacologic and toxic activities of E-Caprolactam.
- Author:
- Hohensee, F.
- Year:
- 1 951
- Bibliographic source:
- Fiber Res. and Textile Tech. 1, 299-303. Cited in: Henschler, D. (Hrsg.), Gesundheitsschaedliche Arbeitsstoffe. Toxikologisch-arbeitsmedizinische Begruendung von MAK-Werten: Caprolactam (1975), 1.-17. Lfg., Verlag Chemie (1991)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Over a time period of 24 days, 5 and 10% of the test substance was applied daily onto the cornea and the mucosa of the eye (3-4 drops) of 2 animals.
- GLP compliance:
- no
Test material
- Reference substance name:
- ε-caprolactam
- EC Number:
- 203-313-2
- EC Name:
- ε-caprolactam
- Cas Number:
- 105-60-2
- Molecular formula:
- C6H11NO
- IUPAC Name:
- azepan-2-one
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- physiological saline
- Controls:
- not specified
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- 2
Results and discussion
Any other information on results incl. tables
No irritation was observed.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- No irritation was observed in rabbits.
- Executive summary:
Over a time period of 24 days, 5 and 10% of the test substance was applied daily onto the cornea and the mucosa of the eye (3-4 drops) of 2 rabbits. No irritation was observed.
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