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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No data on GLP and OECD guidelines compliance

Data source

Reference
Reference Type:
secondary source
Title:
No information
Author:
Bingham, E.; Cohrssen, B.; Powell, C.H.
Year:
2001
Bibliographic source:
Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 4:1329

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,6-trichloro-1,3,5-triazine
EC Number:
203-614-9
EC Name:
2,4,6-trichloro-1,3,5-triazine
Cas Number:
108-77-0
Molecular formula:
C3Cl3N3
IUPAC Name:
2,4,6-trichloro-1,3,5-triazine

Test animals

Species:
rabbit
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
No data
Doses:
10 g/kg and others
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: NOAEL
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No deaths and no evidence of resorption or systemic toxicity, even at doses up to 10 g/kg.
Mortality:
No mortality
Clinical signs:
Severe skin irritation
Body weight:
No data
Gross pathology:
No data
Other findings:
No evidence of resorption or systemic toxicity

Applicant's summary and conclusion

Conclusions:
Severe skin irritation, when appplied to the skin.
No deaths, no evidence of resorption or systemic toxicity, even at doses up to 10 g/kg.
Executive summary:

In an acute exposure study, when cyanuric chloride was applied to the skin of rabbits,it produced severe skin irritation,but no deaths and no evidence of resorption or systemic toxicity, even at doses up to 10 g/kg.