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EC number: 931-330-1 | CAS number: 69227-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- September, 2021 to October, 2022
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Refer to the section 13 for details on the category justification.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Version / remarks:
- 2012
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Samples will be taken from the control and each surviving test group from freshly prepared test
solutions (without food) and the corresponding aged test solutions (with food). Replicate vessels
will be pooled to give one sample. Sampling of the test solutions will start with day 0 samples
and will be performed at least once per week throughout the test. Two renewal periods of 48
hours and one renewal period of 72 hours (weekend) will be chosen for sampling. - Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The study was performed with young daphnids of the species Daphnia magna Straus, which
is the preferred test species recommended by the test guideline. A clone of this species was
originally supplied by Daphnia Collection of the University of Basel/Switzerland in 2015. The
clone is successfully bred at IES Ltd under temperature and light conditions identical to those of
the test.
Each stock animal was maintained separately in a 100 mL glass beaker filled with about 80 mL
Elendt M7 medium and was transferred twice a week to fresh medium. During the culturing period,
the parental daphnidswere fed three times a week with an algal suspension and a Tetramin®
suspension. Details are documented in the culturing records. Culture conditions ensure that
reproduction will be by parthenogenesis. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Post exposure observation period:
- None
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- other: Mortality and inhibition of reproduction
- Details on results:
- See attachment.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the NOEC was equivalent to 2.2 mg/L (Loading Rate) based on mortality and inhibition of reproduction.
- Executive summary:
A study was conducted to evaluate the potential toxicity of the read across substance amides, C12-18 and C18-unsatd., N-(hydroxyethyl) on the survival, growth, and reproduction of Daphnia magna during the exposure period of three weeks. The daphnids were exposed in a semi-static test to aqueous test media containing the test substance at various concentrations. The mortality, reproduction, and body length of the daphnids, as well as the intrinsic rate of reproduction, at the different test concentrations were compared with the corresponding parameters in the control. Additionally, the test animals were observed for visible abnormalities. Under the study conditions, the NOEC was equivalent to 2.2 mg/L (Loading Rate) based on mortality and inhibition of reproduction (Dupont, 2022).
Reference
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 2.2 mg/L
Additional information
A study was conducted to evaluate the potential toxicity of the read across substance amides, C12-18 and C18-unsatd., N-(hydroxyethyl) on the survival, growth, and reproduction of Daphnia magna during the exposure period of three weeks. The daphnids were exposed in a semi-static test to aqueous test media containing the test substance at various concentrations. The mortality, reproduction, and body length of the daphnids, as well as the intrinsic rate of reproduction, at the different test concentrations were compared with the corresponding parameters in the control. Additionally, the test animals were observed for visible abnormalities. Under the study conditions, the NOEC was equivalent to 2.2 mg/L (Loading Rate) based on mortality and inhibition of reproduction (Dupont, 2022).
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