Chromium trioxide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Limited reporting (study summary only) of a guideline-comparable study.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1987

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

GLP compliance:

yes

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Chromic acid

EC Number:

231-801-5

EC Name:

Chromic acid

Cas Number:

7738-94-5

Molecular formula:

CrH2O4

IUPAC Name:

dihydroxy(dioxo)chromium

Details on test material:

Test material name: chromic acid
No further details reported

Test animals

Species:

rat

Strain:

Fischer 344

Sex:

male/female

Details on test animals or test system and environmental conditions:

Not reported

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

No further details reported

Doses:

0, 32, 40, 50, 63, 80 & 100 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

52 mg/kg bw

95% CL:

>= 42 - <= 62

Mortality:

Deaths occurred at 32 mg/kg bw (1M, 2F), 40 mg/kg bw (1M), 50 mg/kg bw (2M, 3F), 63 mg/kg bw (3M, 4F), 80 mg/kg bw (3M, 4F) and 100 mg/kg bw (5M, 5F), within three days of dosing.

Clinical signs:

other: Lacrimation, hunched posture, hypoactivity, soft/reduced faeces, anogenital staining, red/brown facial staining.

Gross pathology:

Findings were apparent in the stomach, intestines, brain, kidney and lungs in decedent animals in all groups, but may have been secondary effects. No effects of treatment were apparent in animals surviving to scheduled necropsy.

Other findings:

Slightly increased liver weights

Any other information on results incl. tables

The report indicates that the primary cause of death was gastrointestinal corrosion, rather than systemic toxicity.

Applicant's summary and conclusion

Interpretation of results:

other: Toxic if swallowed based on EU GHS criteria

Conclusions:

The acute oral LD50 of chromic acid was found to be 52 (42-62) mg/kg bw in the rat. Chromic acid is classified as 'Toxic if swallowed', based on the results of this study.

Executive summary:

Fischer 344 rats (5/sex/group) were gavaged with a single dose of chromic acid at dose levels of 0, 32, 40, 50, 63, 80 or 100 mg/kg bw and observed for 14 days. Deaths occurred in all dose groups, within 3 days of dosing. Reduced weight gain or initial weight loss was apparent in all groups. Gross necropsy of decedents revealed corrosive effects on the gastrointestinal tract. The acute oral LD50 of chromic acid in the rat was found to be 52 (42-62) mg/kg bw.