Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Justification for classification or non-classification

Ethyl vinyl ether, methyl vinyl ether (MVE, CAS 107 -25 -5), isobutyl vinyl ether (IBVE, CAS 109-53-5) and hydroxybutylvinylether (HBVE, CAS 17832 -28 -9) were not mutagenic in the Ames test or in mammalian cell systems (EVE, IBVE, HBVE) both in the absence and presence of metabolic activation. EVE, IBVE and HBVE did not induce chromosomal aberrations in Chinese Hamster cells. In vivo, MVE did not induce micronuclei in bone marrow of mice. The members of this category appear to have no potential to induce gene mutations or chromosomal aberrations.

EVE is practically exclusively used as intermediate in the manufacture of vinyl ether polymers and co-polymers.

Worker exposure to EVE is controlled by the use of closed systems, industrial hygiene controls, and personal protective equipment (OECD SIDS 2006) (see chapter 13). Potentially existing residual EVE is expected to evaporate during the process of heat-treatment (OECD SIDS 2006). Therefore, no exposure of the general population is expected. Taking into account the lack of genotoxic effects, it is concluded that carcinogenicity should not be an endpoint of concern.

Additional information

No carcinogenicity study available.