Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-718-4 | CAS number: 109-92-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
EVE gave negative results in the standard plate test on S. typhimurium TA1535, TA100, TA1537, and TA98 both in the absence and in the presence of a metabolic activation system at concentrations up to 5000 µg/plate and saturated atmosphere (additional petri dishes with EVE) during the 4 -hrs exposure period at 37°C in desiccators to account for the high volatiliy of the test material (BASF 1993; Guideline study). EVE was not tested in S. typhimurium TA102 or in E. coli WP2uvrA, however, oxidizing or cross linking activity of the test substance is not expected.
In the HPRT assay (BASF 1998; Guideline study) conducted with Chinese hamster V79 cells with concentrations up to and including 720 µg/mL (ca. 10 mM; max. concentration recommended in current Guidelines), EVE did not induce an increase in the mutant frequency both with and without metabolic activation (exposure also in sealed culture flasks).
In a cytogenetic study (BASF 1998) according to current guidelines V79 cells were exposed in sealed petri dishes with and without metabolic activation for 4 h to up to 720 µg/mL (10 mM, recommended max. concentration) and harvested 18 and 28 hrs after start of exposure. In a 2nd trial without metabolic activation cells were exposed for 18 (sealed dishes) or 28 h (un-sealed) immediately followed by preparation. No cytotoxic effects were seen and no clastogenic or aneugenic activity.
Short description of key information:
In in vitro assays no gene mutagenic activity was detected in
bacteria and mammalian cells.
No clastogenic or aneugenic effects were found in an in vitro chromosome
aberration assay.
Data on genotoxicity in vivo are not available.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Classification is not warranted according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
