Ethyl vinyl ether

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions. Restriction: purity of test substance not stated; no data on clinical signs; no necropsy; only males.

Data source

Reference

Reference Type:

publication

Title:

Range-finding toxicity data: List VII.

Author:

Smyth HF, Carpenter CP, Weil CS, Pozzani U, Striegel JA, Nygum JS

Year:

1969

Bibliographic source:

Am Ind Hyg Assoc J 30: 470-476

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

no

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl vinyl ether

EC Number:

203-718-4

EC Name:

Ethyl vinyl ether

Cas Number:

109-92-2

Molecular formula:

C4H8O

IUPAC Name:

ethoxyethene

Details on test material:

ethyl vinyl ether (EVE), no further data

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male

Details on test animals or test system and environmental conditions:

Male albino New Zealand rabbits weighing 2.5 to 3.5 kg were used.

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

Groups of 4 animals were used. Dosages up to 20 mL/kg bw were placed on the shaved rabbit skin under occlusive dressing. The animals were immobilized during the 24 hour contact period.

Duration of exposure:

24 h

Doses:

15000 mg/kg bw

No. of animals per sex per dose:

4

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- no data about clinical signs & body weight

Statistics:

LD50-values were estimated by the method of Thompson using the tables of Weil, based on mortalities noted during the 14-day observation period.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

> 15 080 mg/kg bw

Remarks on result:

other: corresponding to 20 mL/kg bw

Any other information on results incl. tables

No further data available.

Applicant's summary and conclusion

Conclusions:

In male New Zealand White rabbits the maximum applied dose volume of 20 mL/kg bw did not induce lethal effects in 4 New Zealand White rabbits after an exposure period of 24 h (occlusive; post exposure period 14 days), therefore the LD50 is >20 mL/kg bw, i.e. > 15080 mg/kg bw.