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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions. Restriction: purity of test substance not stated; no data on clinical signs; no necropsy; only males.

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: List VII.
Author:
Smyth HF, Carpenter CP, Weil CS, Pozzani U, Striegel JA, Nygum JS
Year:
1969
Bibliographic source:
Am Ind Hyg Assoc J 30: 470-476

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl vinyl ether
EC Number:
203-718-4
EC Name:
Ethyl vinyl ether
Cas Number:
109-92-2
Molecular formula:
C4H8O
IUPAC Name:
ethyl vinyl ether
Details on test material:
ethyl vinyl ether (EVE), no further data

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
Male albino New Zealand rabbits weighing 2.5 to 3.5 kg were used.

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Groups of 4 animals were used. Dosages up to 20 mL/kg bw were placed on the shaved rabbit skin under occlusive dressing. The animals were immobilized during the 24 hour contact period.
Duration of exposure:
24 h
Doses:
15000 mg/kg bw
No. of animals per sex per dose:
4
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- no data about clinical signs & body weight
Statistics:
LD50-values were estimated by the method of Thompson using the tables of Weil, based on mortalities noted during the 14-day observation period.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 15 080 mg/kg bw
Remarks on result:
other: corresponding to 20 mL/kg bw

Any other information on results incl. tables

No further data available.

Applicant's summary and conclusion

Conclusions:
In male New Zealand White rabbits the maximum applied dose volume of 20 mL/kg bw did not induce lethal effects in 4 New Zealand White rabbits after an exposure period of 24 h (occlusive; post exposure period 14 days), therefore the LD50 is >20 mL/kg bw, i.e. > 15080 mg/kg bw.