Registration Dossier
Registration Dossier
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EC number: 203-718-4 | CAS number: 109-92-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions. Restriction: purity of test substance not stated; no data on clinical signs; no necropsy; only males.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII.
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani U, Striegel JA, Nygum JS
- Year:
- 1 969
- Bibliographic source:
- Am Ind Hyg Assoc J 30: 470-476
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Ethyl vinyl ether
- EC Number:
- 203-718-4
- EC Name:
- Ethyl vinyl ether
- Cas Number:
- 109-92-2
- Molecular formula:
- C4H8O
- IUPAC Name:
- ethoxyethene
- Details on test material:
- ethyl vinyl ether (EVE), no further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Male albino New Zealand rabbits weighing 2.5 to 3.5 kg were used.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Groups of 4 animals were used. Dosages up to 20 mL/kg bw were placed on the shaved rabbit skin under occlusive dressing. The animals were immobilized during the 24 hour contact period.
- Duration of exposure:
- 24 h
- Doses:
- 15000 mg/kg bw
- No. of animals per sex per dose:
- 4
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- no data about clinical signs & body weight - Statistics:
- LD50-values were estimated by the method of Thompson using the tables of Weil, based on mortalities noted during the 14-day observation period.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 15 080 mg/kg bw
- Remarks on result:
- other: corresponding to 20 mL/kg bw
Any other information on results incl. tables
No further data available.
Applicant's summary and conclusion
- Conclusions:
- In male New Zealand White rabbits the maximum applied dose volume of 20 mL/kg bw did not induce lethal effects in 4 New Zealand White rabbits after an exposure period of 24 h (occlusive; post exposure period 14 days), therefore the LD50 is >20 mL/kg bw, i.e. > 15080 mg/kg bw.
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