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Registration Dossier
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EC number: 203-718-4 | CAS number: 109-92-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Ethyl vinyl ether
- EC Number:
- 203-718-4
- EC Name:
- Ethyl vinyl ether
- Cas Number:
- 109-92-2
- Molecular formula:
- C4H8O
- IUPAC Name:
- ethoxyethene
- Details on test material:
- ethyl vinyl ether (EVE)
purity > 99.5%
stability during experiment was given
no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K . Thomae GmbH, Biberach
- Age at study initiation: 8-9 weeks
- Weight at study initiation: males 257+-10 g and females 185+-10 g
- Fasting period before study: no data
- Housing: singly
- Diet ad libitum, certified diet (analysed for contaminations)
- Tap water ad libitum (analysed for contaminations)
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Details on inhalation exposure:
- The animals were singly placed into compartments of an inhalation chamber (glass-steel, volume 200 L). Atmosphere was dynamically generated. Air passed an evaporator to which TS was pumped. Vapours were mixed with fresh air. Air was delivered to the inhalation chamber at a rate of 3000 L/h.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- [concentration measured by gas chromatography (calibration; 4 samples measured)]
- Duration of exposure:
- 4 h
- Concentrations:
- 21.2 mg/L (mean of 4 samples; comment: in OECD Guideline 5 mg/L recommended for the limit test)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: clinical observations during exposure at least once daily thereafter
- Necropsy of survivors performed: yes
- body weight: once weekly (day 0, 7, 14) - Statistics:
- not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 21.2 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: (7200 ppm) no lethal effects in males and females
- Mortality:
- no mortality
- Clinical signs:
- other: During exposure: marked apathia, closed lids, depressed breathing, unkempt fur. After exposure: unkempt fur. No symptoms were noted from the day following exposure.
- Body weight:
- Body weight development of male and female rats was comparable to historical control data over the entire observation period.
- Gross pathology:
- no effects detected
- Other findings:
- no
Applicant's summary and conclusion
- Conclusions:
- In the Limit test in 5 male and 5 female Wistar rats (according to OECD Guideline 403) no mortality was found but clinical signs (sedation) at a concentration of 21 mg/L (7200 ppm) and an exposure duration of 4 h. Apathy, closed lids and depressed breathing were noted during exposure, these clinical signs were absent the following day. No effects were detcted at necropsy 2 weeks after exposure.
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