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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions. Restriction: purity of TS not reported; non-fasted animals; no data about vehicle; no data about clinical signs, necropsy or body weight.

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: List VII.
Author:
Smyth HF, Carpenter CP, Weil CS, Pozzani U, Striegel JA, Nygum JS
Year:
1969
Bibliographic source:
Am Ind Hyg Assoc J 30: 470-476

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
Principles of method if other than guideline:
Methods according to Smyth et al., Am Ind Hyg Assoc J 23: 95ff (1962).
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl vinyl ether
EC Number:
203-718-4
EC Name:
Ethyl vinyl ether
Cas Number:
109-92-2
Molecular formula:
C4H8O
IUPAC Name:
ethoxyethene
Details on test material:
Ethyl vinyl ether, no further data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
Male Carworth-Wistar rats were used, four to five weeks of age and 90 to 120 g in weight. Animals were kept on complete diet.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
no further details
Doses:
Dose levels were arranged in a logarithmic series differing by a factor of 2.
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
Post exposure observation period 14 days
Statistics:
LD50-values were estimated by the method of Thompson using the tables of Weil, based on mortalities.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
6 150 mg/kg bw
95% CL:
5 300 - 7 150
Remarks on result:
other: original value: 8.16 mL/kg bw

Any other information on results incl. tables

No further details given. 
Density: 0.754 g/mL at 20°C.

Applicant's summary and conclusion

Conclusions:
The LD50 in male Wistar rats was 8.16 mL/kg bw corresponding to 6150 mg/kg bw; the post exposure observation period was 14 days.