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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference
Title:
No information
Author:
Krantz JC, Carr CJ, Musser RD, and Sauerwald, MJ (1947). The|anestetic action of ethyl vinyl ether. J Pharmacol Exp Ther|90, 88-94.

Materials and methods

Type of study / information:
Type: other: pharmacological evaluation.

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl vinyl ether
EC Number:
203-718-4
EC Name:
Ethyl vinyl ether
Cas Number:
109-92-2
Molecular formula:
C4H8O
IUPAC Name:
ethyl vinyl ether

Results and discussion

Any other information on results incl. tables

RS-Freetext:
In the animal studies using various species (rat, frog, dog,
monkeys), EVE did not significantly change blood pressure,
Electrocardiogram (ECG), Electroencephalogram (EEG), blood
urea, carbon dioxide combining power. There was no
hemolysis. Clotting time was increased by 10-15%. Liver
function was normal, and there were no pathological changes
noted in liver and kidney.

Applicant's summary and conclusion