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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets scientific standards but limited exposure data.

Data source

Reference
Reference Type:
publication
Title:
The anaesthetic action of ethyl vinyl ether
Author:
Krantz JC, Carr CJ, Mussler R, Sauerwald MJ
Year:
1947
Bibliographic source:
J Pharmacol Exp Therap 30: 88-94

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
acute toxicity: inhalation
Principles of method if other than guideline:
Narcosis in humans studied
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl vinyl ether
EC Number:
203-718-4
EC Name:
Ethyl vinyl ether
Cas Number:
109-92-2
Molecular formula:
C4H8O
IUPAC Name:
ethoxyethene
Details on test material:
ethyl vinyl ether (EVE)
no further data

Method

Type of population:
other: medical staff
Subjects:
1 female volunteer
Ethical approval:
not specified
Route of exposure:
inhalation
Reason of exposure:
intentional
Exposure assessment:
not specified
Details on exposure:
Application by the open drop method (common method in 1947)
Examinations:
narcosis, blood pressure and pulse
Medical treatment:
no

Results and discussion

Results of examinations:
The induction period for anaestheia was about 60 seconds. Light anesthesia was continued for about 6 minutes. The recovery was rapid and uneventful. The blood
pressure and pulse were not significantly altered. The subject stated that the vapours did not irritate the upper respiratory tract.

Applicant's summary and conclusion

Conclusions:
In a female volunteer narcosis was induced by the the open drop method. The blood pressure and pulse were not significantly altered. She reported no irritation of the respiratory tract after acute inhalation of presumably saturated vapour.