Registration Dossier
Registration Dossier
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EC number: 203-718-4 | CAS number: 109-92-2
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards
Data source
Reference
- Reference Type:
- publication
- Title:
- Nonspecific stimulation of drug-metabolizing enzymes by inhalation anesthetic agents.
- Author:
- Linde HW and Berman ML
- Year:
- 1 971
- Bibliographic source:
- Anesth Analg 50: 656-667.
Materials and methods
- Principles of method if other than guideline:
- Increase in hexobarbital sleeping time in rats after inhalation exposure to the EVE
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- Ethyl vinyl ether
- EC Number:
- 203-718-4
- EC Name:
- Ethyl vinyl ether
- Cas Number:
- 109-92-2
- Molecular formula:
- C4H8O
- IUPAC Name:
- ethoxyethene
- Details on test material:
- ethyl vinyl ether (EVE)
no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 40 to 60 g body weight
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- other: air
- Details on exposure:
- exposure duration 7 h
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- GC analysis
- Duration of treatment / exposure:
- 7 h/day
- Frequency of treatment:
- One or two days
- Post exposure period:
- 3-5 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.9% v/v
Basis:
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent no treatment
Results and discussion
Any other information on results incl. tables
RS-Freetext:
Compared to control rats the Hexobarbital sleeping time was
reduced to 72% (without gaining statistical significance) in
rats exposed to EVE on one day, and to 54% (p<0.005) in rats
that were exposed on two days.
Applicant's summary and conclusion
- Conclusions:
- EVE treatment increased in rats the hexobarbital sleeping time 3-5 days after the last inhalation exposure (7 h to 0.9% v/v; 26 mg/L) on two consecutive days suggesting induction of drug metabolizing enzymes.
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