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Diss Factsheets

Administrative data

Endpoint:
biochemical or cellular interactions
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards

Data source

Reference
Reference Type:
publication
Title:
Nonspecific stimulation of drug-metabolizing enzymes by inhalation anesthetic agents.
Author:
Linde HW and Berman ML
Year:
1971
Bibliographic source:
Anesth Analg 50: 656-667.

Materials and methods

Principles of method if other than guideline:
Increase in hexobarbital sleeping time in rats after inhalation exposure to the EVE
GLP compliance:
no
Type of method:
in vivo
Endpoint addressed:
not applicable

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl vinyl ether
EC Number:
203-718-4
EC Name:
Ethyl vinyl ether
Cas Number:
109-92-2
Molecular formula:
C4H8O
IUPAC Name:
ethoxyethene
Details on test material:
ethyl vinyl ether (EVE)
no further data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals or test system and environmental conditions:
40 to 60 g body weight

Administration / exposure

Route of administration:
inhalation: vapour
Vehicle:
other: air
Details on exposure:
exposure duration 7 h
Analytical verification of doses or concentrations:
yes
Details on analytical verification of doses or concentrations:
GC analysis
Duration of treatment / exposure:
7 h/day
Frequency of treatment:
One or two days
Post exposure period:
3-5 days
Doses / concentrations
Remarks:
Doses / Concentrations:
0.9% v/v
Basis:

No. of animals per sex per dose:
5
Control animals:
yes, concurrent no treatment

Results and discussion

Any other information on results incl. tables

RS-Freetext:
Compared to control rats the Hexobarbital sleeping time was
reduced to 72% (without gaining statistical significance) in
rats exposed to EVE on one day, and to 54% (p<0.005) in rats
that were exposed on two days.

Applicant's summary and conclusion

Conclusions:
EVE treatment increased in rats the hexobarbital sleeping time 3-5 days after the last inhalation exposure (7 h to 0.9% v/v; 26 mg/L) on two consecutive days suggesting induction of drug metabolizing enzymes.