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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
neurotoxicity: acute inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards.

Data source

Reference
Reference Type:
publication
Title:
The anaesthetic action of ethyl|vinyl ether.
Author:
Krantz JC, Carr CJ, Mussler R, Sauerwald MJ
Year:
1947
Bibliographic source:
J Pharmacol Exp Therap 30: 88-94

Materials and methods

Principles of method if other than guideline:
Narcotic effects in different species studied
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl vinyl ether
EC Number:
203-718-4
EC Name:
Ethyl vinyl ether
Cas Number:
109-92-2
Molecular formula:
C4H8O
IUPAC Name:
ethoxyethene
Details on test material:
ethyl vinyl ether (EVE)
no further data

Test animals

Species:
other: rat, monkey, dog, frog, man
Strain:
not specified
Details on test animals or test system and environmental conditions:
no details

Administration / exposure

Route of administration:
inhalation
Vehicle:
other: air
Details on exposure:
no details
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
acute inhalation
Frequency of treatment:
once
Doses / concentrations
Remarks:
Doses / Concentrations:
no details, concentration sufficient for anaesthesia
Basis:

No. of animals per sex per dose:
see results

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Mortality:
mortality observed, treatment-related
Details on results:
Narcosis in various species:
A rapid induction of narcosis and rapid recovery from narcosis was noted with monkeys, dogs, rats, and man. Compared with diethylether approx. 50% less the quantity was required.
Dogs: A wide margin of safety of 3.0 was noted between induction of narcosis and respiratory failure.
Man: EVE narcosis was also studied in one human subject. The induction period was 60 seconds, duration of light anaesthesia was 6 minutes. Recovery was rapid and uneventful. Blood pressure and pulse were not altered. The subject stated that the vapors did not irritate the upper respiratory tract.
Further endpoints studied: Liver and kidneys: no changes noted in bromosulphthalein excretion and histopathology in rat, dog, and monkey. Liver biopsy did not reveal changes in three dogs and in 2 monkeys (macaca mulatta) 5 days after the first treatment. Heart, blood pressure: no significant changes noted in blood pressure and electrocardiogram. Clotting time, hemolysis: clotting time was increased by 10-15% in monkeys under EVE anaethesia. No hemolysis was noted when 0.1 mL of defribrinated dog's blood was added to 10 mL salt solutions containing 10, 25, or 50 mg% of EVE.

Any other information on results incl. tables

Authors comment: Promising anaesthetic in man, no undesired side effects; 
large margin of safety found in dogs.

Applicant's summary and conclusion

Conclusions:
Promising anaesthetic properties of EVE were noted in
various species including man. Narcotic potency of EVE was
larger than that of diethylether.