Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
neurotoxicity: acute inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards.

Data source

Reference
Reference Type:
publication
Title:
The anaesthetic action of ethyl|vinyl ether.
Author:
Krantz JC, Carr CJ, Mussler R, Sauerwald MJ
Year:
1947
Bibliographic source:
J Pharmacol Exp Therap 30: 88-94

Materials and methods

Principles of method if other than guideline:
Narcotic effects in different species studied
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl vinyl ether
EC Number:
203-718-4
EC Name:
Ethyl vinyl ether
Cas Number:
109-92-2
Molecular formula:
C4H8O
IUPAC Name:
ethyl vinyl ether
Details on test material:
ethyl vinyl ether (EVE)
no further data

Test animals

Species:
other: rat, monkey, dog, frog, man
Strain:
not specified
Details on test animals or test system and environmental conditions:
no details

Administration / exposure

Route of administration:
inhalation
Vehicle:
other: air
Details on exposure:
no details
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
acute inhalation
Frequency of treatment:
once
Doses / concentrations
Remarks:
Doses / Concentrations:
no details, concentration sufficient for anaesthesia
Basis:

No. of animals per sex per dose:
see results

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Mortality:
mortality observed, treatment-related
Details on results:
Narcosis in various species:
A rapid induction of narcosis and rapid recovery from narcosis was noted with monkeys, dogs, rats, and man. Compared with diethylether approx. 50% less the quantity was required.
Dogs: A wide margin of safety of 3.0 was noted between induction of narcosis and respiratory failure.
Man: EVE narcosis was also studied in one human subject. The induction period was 60 seconds, duration of light anaesthesia was 6 minutes. Recovery was rapid and uneventful. Blood pressure and pulse were not altered. The subject stated that the vapors did not irritate the upper respiratory tract.
Further endpoints studied: Liver and kidneys: no changes noted in bromosulphthalein excretion and histopathology in rat, dog, and monkey. Liver biopsy did not reveal changes in three dogs and in 2 monkeys (macaca mulatta) 5 days after the first treatment. Heart, blood pressure: no significant changes noted in blood pressure and electrocardiogram. Clotting time, hemolysis: clotting time was increased by 10-15% in monkeys under EVE anaethesia. No hemolysis was noted when 0.1 mL of defribrinated dog's blood was added to 10 mL salt solutions containing 10, 25, or 50 mg% of EVE.

Any other information on results incl. tables

Authors comment: Promising anaesthetic in man, no undesired side effects; 
large margin of safety found in dogs.

Applicant's summary and conclusion

Conclusions:
Promising anaesthetic properties of EVE were noted in
various species including man. Narcotic potency of EVE was
larger than that of diethylether.