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Ecotoxicological information

Long-term toxicity to fish

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Description of key information

NOEC (28 d, mortality) = 1.8 mg a.i./L for Brachydanio rerio (OECD 204) (read-across)

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater fish:
1.8 mg/L

Additional information

There are no data available on long-term toxicity to fish of Reaction products of D-Glucose, n-Butanol and C10-12 (even numbered) alcohols.However, there are reliable data for category member substances which are considered suitable for read-across based on a category approach. This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 and justified in detail in the overall summary (IUCLID Chapter 6.1) and within the category justification attached in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. Nevertheless, as it can be seen in the data matrix of the category justification in IUCLID Section 13 and the overall summary (IUCLID Chapter 6.1), all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results.

One guideline study investigating the long-term toxicity of the category member D-Glucopyranose, oligomeric, C10-16-alkyl glycosides to fish is available. The toxicity of the substance to the zebrafish Brachydanio rerio was tested in a prolonged fish toxicity test according to OECD guideline 204 and GLP for 28 days (TNO, 1995). This test can be used as a long-term test because the following criteria are fulfilled: the duration is 28 days, the tested fish life stage is equal to OECD 215 and additional parameters like behaviour and growth were investigated (according to “Guidance Document on Aquatic Ecotoxicology” published by the European Commission (2002)). The test exhibited a NOEC of 1.8 mg a.i./L after 28 days for mortality and a NOEC of 3.2 mg a.i./L for growth, respectively. No behavioral abnormalities were observed in the non-toxic concentrations of the test substance.