Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

MPAAU is expected to have good bioavailability when exposed via the oral and inhalation route. Based on data of an in-vitro dermal penetration test the bioavailability via the dermal route is low (<5%). Bioaccumulation is not expected because of the low log Pow. There is no indication of metabolism. Excretion via urine is regarded to be the preferred way of elimination. 

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
5
Absorption rate - inhalation (%):
100

Additional information

There is evidence from available toxicity studies and physico-chemical properties that MPAAU was absorbed and distributed systemically when administered orally. Short-term toxicity studies with relatively large doses of MPAAU suggest that absorbed MPAAU and potential metabolites are rapidly eliminated without impact to the test animals. MPAAU and its potential metabolites do not present a genotoxic hazard and do not cause significant local or systemic toxicity in animals.

Bioaccumulation is not expected because of the low log Pow.

MPAAU showed very low penetration through the skin of porcine ears. Within 8 hours no percoutaneous penetration was detected. Within 24 hours less than 5 % (mean value) of the amount of substance applied to the test system penetrated.