Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

The substance is an UVCB generated by the reaction of glycerol, propane-1,3-diol and trimellitic anhydride. It is expected that the starting materials or their hydrolysis products are released in the course of metabolism. Esterases present in the skin, in the interstinal tissues and in liver and plasma can efficiently cleave similar esters. 

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
50
Absorption rate - dermal (%):
1
Absorption rate - inhalation (%):
100

Additional information

The dermal absorption has been modeled according to Fitzpatrick et al.. The log Kp calculated with a mol wt. of 920 and a logKow of 0.3 is -12.2 indicating a marginal potential for skin penetration.

D. Fitzpatrick, J. Corish, B. Hayes: Modelling skin permeability in risk assessment–the future. Chemosphere 55 (2004) 1309–1314