Registration Dossier
Registration Dossier
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EC number: 231-208-1 | CAS number: 7446-70-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Magnusson, B. and Kligman, A.M.
- Year:
- 1 969
- Bibliographic source:
- J. Invest.Dermatol. 52, 268-276, cited in: Gad, S.C. et al.: Toxicol. Appl.Pharmacol. 84, 93-114 (1986) and Vial, T. and Descotes, J.: Toxicology 93, 63-75 (1995)
Materials and methods
- Principles of method if other than guideline:
- according to Magnusson and Kligman
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Aluminium chloride
- EC Number:
- 231-208-1
- EC Name:
- Aluminium chloride
- Cas Number:
- 7446-70-0
- Molecular formula:
- AlCl3
- IUPAC Name:
- trichloroalumane
- Details on test material:
- no data on purity of the compound
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- petrolatum
- Concentration / amount:
- intradermal induction: 2%
topical induction: 25%
challenge: 2%
Challenge
- Concentration / amount:
- intradermal induction: 2%
topical induction: 25%
challenge: 2%
- No. of animals per dose:
- no data
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
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