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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature

Data source

Reference
Reference Type:
secondary source
Title:
No information
Author:
Magnusson, B. and Kligman, A.M.
Year:
1969
Bibliographic source:
J. Invest.Dermatol. 52, 268-276, cited in: Gad, S.C. et al.: Toxicol. Appl.Pharmacol. 84, 93-114 (1986) and Vial, T. and Descotes, J.: Toxicology 93, 63-75 (1995)

Materials and methods

Principles of method if other than guideline:
according to Magnusson and Kligman
GLP compliance:
no
Type of study:
guinea pig maximisation test

Test material

Constituent 1
Chemical structure
Reference substance name:
Aluminium chloride
EC Number:
231-208-1
EC Name:
Aluminium chloride
Cas Number:
7446-70-0
Molecular formula:
AlCl3
IUPAC Name:
aluminum trichloride
Details on test material:
no data on purity of the compound

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
intradermal
Vehicle:
petrolatum
Concentration / amount:
intradermal induction: 2%
topical induction: 25%
challenge: 2%
Challenge
Concentration / amount:
intradermal induction: 2%
topical induction: 25%
challenge: 2%
No. of animals per dose:
no data

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information