Registration Dossier
Registration Dossier
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EC number: 231-208-1 | CAS number: 7446-70-0
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: basic information given
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of Pressure on Contact Dermatitis.
- Author:
- Gollhausen, R. and Kligman, A.M.
- Year:
- 1 985
- Bibliographic source:
- Am.J.Ind.Med. 8, 323-328
Materials and methods
- Principles of method if other than guideline:
- Irritant chemicals were tested in paid volunteers in a closed chamber test.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Aluminium chloride
- EC Number:
- 231-208-1
- EC Name:
- Aluminium chloride
- Cas Number:
- 7446-70-0
- Molecular formula:
- AlCl3
- IUPAC Name:
- trichloroalumane
- Test material form:
- other: aquaeous solution, saturated
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- Groups of five to seven young, adult, white, paid volunteers.
- Exposure assessment:
- not specified
- Details on exposure:
- Test agents were applied to the inner forearm using 19-mm-diameter closed chambers that resembled Duhring Chambers (Frosch and Kligman, Contact Dermatitis, 1979 Mar;5(2):73-81) but were made of deformable plastic instead of rigid aluminum. The chambers were designed to ensure nonleakage, complete occlusion, intimacy of contact, and uniform exposure. The chamber was filled with two thicknesses of nonwoven cotton disks (WebrilR), and 0.1 to 0.2 ml of test fluid was instilled onto the cotton disks (enough to wet the pads without spillover). Pressure to the treated skin areas wasapplied by placing a 9-mm-diameter wood bead atop the chamber and then tightly, encircling the forearm with adhesive tape . The bead depresses the top, forcing the wetted cotton pad to press against the skin. The tests were conducted in pairs, one with and one without pressure (the control). Irritants were applied for 1 to 3 days and were read 30 minutes after removal.
Results and discussion
- Results:
- Aluminium chloride caused moderate confluent redness (grade 2+).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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