Aluminium chloride

Toxicity to birds

Administrative data

Endpoint:

short-term toxicity to birds: dietary toxicity test

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given, acceptable study which meets basic scientific principles.

Data source

Reference

Reference Type:

publication

Title:

Use of High Leveis of Dietary Aluminum and Zinc for Inducing Pauses in Egg Production of Japanese Quail.

Author:

Hussein AS et al.

Year:

1988

Bibliographic source:

Poultry Science 67: 1157-1165

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The study was conducted in three different trials. The objective of the first trial was to compare the effects of high levels of dietary Al and Zn upon induction of pauses in egg production and subsequent performance of Japanese quail laying hens. The objective of the second trail was to determine the effect of dietary Zn and Al in combination with decreased day length for inducing pauses in egg production. The objective of Trial 3 was to determine the influence of graded levels of dietary Al on the performance of Japanese quail laying hens using levels lower then 0.3% Al in order to prevent complete cessation of egg production.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Aluminium sulphate

EC Number:

233-135-0

EC Name:

Aluminium sulphate

Cas Number:

10043-01-3

Molecular formula:

Al.3/2H2O4S

IUPAC Name:

Aluminium sulphate

Details on test material:

- Chemical name: Aluminium sulphate
- Analytical Purity: no data

Dose method:

feed

Analytical monitoring:

no

Vehicle:

no

Test organisms

Test organisms (species):

Coturnix coturnix japonica

Study design

Limit test:

no

Total exposure duration (if not single dose):

28 d

Results and discussion

Effect levels

Effect levels 1

Duration (if not single dose):

28 d

Dose descriptor:

NOEL

Effect level:

5 000 mg/kg diet

Conc. / dose based on:

element

Remarks:

Al

Basis for effect:

other: egg shell breaking strength, body weight, feed intake

Remarks on result:

other: =0.05% Al in diet

Effect levels 2

Duration (if not single dose):

28 d

Dose descriptor:

NOEL

Effect level:

24 709 mg/kg diet

Conc. / dose based on:

test mat.

Remarks:

AlCl3

Basis for effect:

other: egg shell breaking strength, body weight, feed intake

Remarks on result:

other: =0.05% Al in diet

Any other information on results incl. tables

The effect of using a high level of dietary aluminium (0.3% AI, as aluminum sulfate) was investigated among 4 and 7 days. Results showed that Al treatments significantly (P<0.05) reduced body weight. Egg production approached 0% by Day 3. Egg shell breaking strength was significantly (P<0.05) reduced by dietary Al. Aluminum significantly reduced plasma inorganic P, measured on day 5. In Trial 3 (28 day study), diets containing graded levels (0, 0.05, 0.10, or 0.15%) of Al were fed to Japanese quail hens for 28 days. Both 0.10% and 0.15% Al significantly (P<0.05) reduced egg shell breaking strength during Days 8 through 12 and body weight at Day 28. Feeding 0.15% Al significantly reduced feed intake and egg production.