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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well documented and scientifically acceptable

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977
Reference Type:
publication
Title:
Acute toxicologic evaluation of methylmercaptobenzimidazole
Author:
Bomhard E, Loeser E
Year:
1996
Bibliographic source:
J Am Coll Toxicol 15, S65

Materials and methods

Principles of method if other than guideline:
Seven groups of 10 young adult male Wistar rats (160 -180 g) were dosed at 200, 300, 350, 380, 400, 450, or 500 mg/kg bw Vulkanox MB 2 (CAS 53988-10-6) in Lutrol. The animals were observed for mortality, body weights and clinical signs through day 14
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione
EC Number:
258-904-8
EC Name:
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione
Cas Number:
53988-10-6
Molecular formula:
C8H8N2S
IUPAC Name:
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione
Details on test material:
Versuchsprodukt KA 9059 = Vulkanox MB-2/MG; no further data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
polyethylene glycol
Doses:
200, 300, 350, 380, 400, 450, or 500 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
340 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

Corresponding mortality was 0, 20, 70, 70, 80, 80 and 100% respectively. Sedation was the only clinical sign. Deaths occured on days 1 to 4. The acute oral LD50 for male rats is 340 mg/kg bw (95% confidence interval: 300 - 370 mg/kg bw).

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information
Executive summary:

Seven groups of 10 young adult male Wistar rats (160 -180 g) were dosed at 1 200, 300, 350, 380, 400, 450, or 500 mg/kg bw Vulkanox MB 2 (CAS 53988-10-6) in Lutrol. The animals were observed for mortality, body weights and clinical signs through day 14.

Corresponding mortality was 0, 20, 70, 70, 80, 80 and 100% respectively. Sedation was the only clinical sign. Deaths occured on days 1 to 4. The acute oral LD50 for male rats is 340 mg/kg bw (95% confidence interval: 300 - 370 mg/kg bw).