Phosphoric acid, mixed esters with 3,3,4,4,5,5,6,6,7,7,8,8,8 –tridecafluorooctan-1-ol and polysubstituted alkane, mono- and diammonium salts

Endpoint summary

Additional information

This multi-constituent substance was tested for acute oral, dermal, and inhalation toxicity. The aqueous dispersion was tested (approx. 20% solids and 80% water) was administered directly without correction for active ingredient in an acute oral up/down study and acute dermal study in rats. In both the acute oral and dermal studies, the material was not toxic and the LD₅₀ was determined to be >5000 mg aqueous dispersion/kg or >1000 mg a.i /kg of the multi-constituent substance. In another acute oral up/down LD₅₀ study, female mice were administered a similar test substance formulation and the LD₅₀ was determined to be >5000 mg aqueous dispersion/kg. A correction for active solids was made and an additional dose was administered with no mortality resulting from >2000 mg a.i./kg. Due to animal welfare considerations, no further oral administrations at higher corrections were made and the oral LD₅₀ can be estimated to be >2000 mg a.i./kg. The Approximate Lethal Concentration (ALC) or the threshold for lethality was the resulting endpoint from this study and was determined to be 86 mg a.i./m³ (respirable particulate), indicating the material may be toxic with inhalation of respirable particulate, the vapour is not expected to be toxic. A full LC₅₀ evaluation has not been conducted on this material or any similar substance. However, an acute toxicity estimation (ATE) can be used to determine classification, therefore, the ATE is 0.05 mg/L and this value will be used to make an acute inhalation classification.

Justification for classification or non-classification

This multi-constituent substance was tested for acute oral, dermal, and inhalation toxicity. The aqueous dispersion was tested (approx. 20% solids and 80% water) was administered directly without correction for active ingredient in an acute oral up/down study and acute dermal study in rats. In both the acute oral and dermal studies, the material was not toxic and the LD₅₀ was determined to be >5000 mg aqueous dispersion/kg or >1000 mg a.i /kg of the multi-constituent substance. In another acute oral up/down LD₅₀ study, female mice were administered a similar test substance formulation and the LD₅₀ was determined to be >5000 mg aqueous dispersion/kg. A correction for active solids was made and an additional dose was administered with no mortality resulting from >2000 mg a.i./kg. Due to animal welfare considerations, no further oral administrations at higher corrections were made and the oral LD₅₀ can be estimated to be >2000 mg a.i./kg. The Approximate Lethal Concentration (ALC) or the threshold for lethality was the resulting endpoint from this study and was determined to be 86 mg a.i./m³ (respirable particulate), indicating the material may be toxic with inhalation of respirable particulate, the vapour is not expected to be toxic. A full LC₅₀ evaluation has not been conducted on this material or any similar substance. However, an acute toxicity estimation (ATE) can be used to determine classification, therefore, the ATE is 0.05 mg/L and this value will be used to make an acute inhalation classification.