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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only summary available

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1984

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydrogen chloride
EC Number:
231-595-7
EC Name:
Hydrogen chloride
Cas Number:
7647-01-0
Molecular formula:
ClH
IUPAC Name:
hydrogen chloride
Details on test material:
Name: hydrogen chloride gas

Test animals

Species:
other: rat and mouse
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
90 days
Frequency of treatment:
6 hours/day - 5 days /week
Doses / concentrationsopen allclose all
Remarks:
Doses / Concentrations:
0 mg/m3
Basis:
no data
Remarks:
Doses / Concentrations:
15 mg/m3
Basis:

Remarks:
Doses / Concentrations:
30 mg/m3
Basis:

Remarks:
Doses / Concentrations:
75 mg/m3
Basis:

No. of animals per sex per dose:
No data

Results and discussion

Effect levels

open allclose all
Dose descriptor:
NOAEL
Effect level:
30 mg/m³ air
Dose descriptor:
LOAEL
Effect level:
15 mg/m³ air
Sex:
male/female
Basis for effect level:
other: LOAEL for irritation

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

- Dose of 75 mg/m3 : Slight but significant decrease in body weight in male and female mice + in male rats

- All doses: No effects in haematology, clinical chemistry and urinalysis parameters. Local irritative effects on the nose was observed in rats and mice

In rats, concentrationand time-dependent minimal to slight rhinitis in the anterior nasal cavity were observed after 5 and 90 days. In mice, dose-dependently increasing lesions on skin and mucosa, particularly around the mouth and nose, were observed after 90 days at or above 30 mg/m3. In mice, histology revealed ulcerative dermatitis, necrotic cells in the subcutis and increased phagocytised blood pigments in macrophages and intracytoplasmatically in sub-epithelial cells.

Applicant's summary and conclusion

Conclusions:
The systemic NOAEL was found to be 30 mg/m3. The LOAEL for irritation was 15 mg/m3