Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 231-714-2 | CAS number: 7697-37-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only summary available
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Hydrogen chloride
- EC Number:
- 231-595-7
- EC Name:
- Hydrogen chloride
- Cas Number:
- 7647-01-0
- Molecular formula:
- ClH
- IUPAC Name:
- hydrogen chloride
- Details on test material:
- Name: hydrogen chloride gas
Constituent 1
Test animals
- Species:
- other: rat and mouse
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- 6 hours/day - 5 days /week
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0 mg/m3
Basis:
no data
- Remarks:
- Doses / Concentrations:
15 mg/m3
Basis:
- Remarks:
- Doses / Concentrations:
30 mg/m3
Basis:
- Remarks:
- Doses / Concentrations:
75 mg/m3
Basis:
- No. of animals per sex per dose:
- No data
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 30 mg/m³ air
- Dose descriptor:
- LOAEL
- Effect level:
- 15 mg/m³ air
- Sex:
- male/female
- Basis for effect level:
- other: LOAEL for irritation
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
- Dose of 75 mg/m3 : Slight but significant decrease in body weight in male and female mice + in male rats
- All doses: No effects in haematology, clinical chemistry and urinalysis parameters. Local irritative effects on the nose was observed in rats and mice
In rats, concentrationand time-dependent minimal to slight rhinitis in the anterior nasal cavity were observed after 5 and 90 days. In mice, dose-dependently increasing lesions on skin and mucosa, particularly around the mouth and nose, were observed after 90 days at or above 30 mg/m3. In mice, histology revealed ulcerative dermatitis, necrotic cells in the subcutis and increased phagocytised blood pigments in macrophages and intracytoplasmatically in sub-epithelial cells.
Applicant's summary and conclusion
- Conclusions:
- The systemic NOAEL was found to be 30 mg/m3. The LOAEL for irritation was 15 mg/m3
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