Nitric acid

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

NA

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only an abstract is available.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

publication

Title:

Effects of breathing nitrate aerosols in high concentration for 10 minutes on pulmonary function of normal and asthmatic adults, and preliminary results in normals exposed to nitric acid fumes.

Author:

Sackner MA and Ford D

Year:

1981

Bibliographic source:

Am. Rev. Resp. Dis. 123: 151.

Materials and methods

Type of study / information:

Preliminary results of adults exposed to nitric acid fumes.

Endpoint addressed:

acute toxicity: inhalation

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

N/A

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Nitric acid

EC Number:

231-714-2

EC Name:

Nitric acid

Cas Number:

7697-37-2

Molecular formula:

HNO3

IUPAC Name:

nitric acid

Test material form:

other: liquid

Details on test material:

- Name of test material (as cited in study report): nitric acid
- Molecular formula (if other than submission substance): N/A
- Molecular weight (if other than submission substance): N/A
- Smiles notation (if other than submission substance): N/A
- InChl (if other than submission substance): N/A
- Structural formula attached as image file (if other than submission substance): N/A
- Substance type: N/A
- Physical state: N/A
- Analytical purity: N/A
- Impurities (identity and concentrations): N/A
- Composition of test material, percentage of components: N/A
- Isomers composition: N/A
- Purity test date: N/A
- Lot/batch No.: N/A
- Expiration date of the lot/batch: N/A
- Radiochemical purity (if radiolabelling): N/A
- Specific activity (if radiolabelling): N/A
- Locations of the label (if radiolabelling): N/A
- Expiration date of radiochemical substance (if radiolabelling): N/A
- Stability under test conditions: N/A
- Storage condition of test material: N/A
- Other: N/A

Method

Ethical approval:

not specified

Details on study design:

Five normal adults were exposed to nitric acid fumes in a concentration of 1.6 ppm in air for 10 minutes.

Exposure assessment:

not specified

Details on exposure:

N/A

Results and discussion

Results:

The vital capacity,total respiratory resistance, and FEV1.0 were not affected over a 1 hour follow up period.

Any other information on results incl. tables

N/A

Applicant's summary and conclusion

Conclusions:

Nitric acid fumes (1.6 ppm) for 10 minutes did not produce acute bronchoconstriction in normal adults.

Executive summary:

N/A