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In aqueous environments, such as the body the magnesium sulphate is completely dissociated into the magnesium (Mg2+) and the sulfate (SO4 2-) ions.

Absorption of sulphate depends on the amount ingested. 30 - 44% of sulfate was excreted in the 24-h urine after oral administration of magnesium or sodium sulfate (5.4 g sulfate) in volunteers. At high sulphate doses that exceed intestinal absorption, sulphate is excreted in feces. Intestinal sulphate may bind water into the lumen and cause diarrhoea in high doses. Sulphate is a normal constituent of human blood and does not accumulate in tissues. Sulphate levels are regulated by the kidney through a reabsorption mechanism. Sulphate is usually eliminated by renal excretion. It has also an important role in the detoxification of various endogenous and exogenous compounds, as it may combine with these to form soluble sulphate esters that are excreted in the urine (EPA, 2002).

Based on low MW, high water solubility, assumed low logPow high absorption is expected. However, the ion formation of the substance inmediately when in contact with a fluid decreases the absorption. The guidance has also been taken into consideration. Therefore, 50% absorption is taken for oral, dermal and inhalation exposure.