Nicotine

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014-09-22 to 2014-09-23

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: The study was performed in accordance with standard test protocols (OECD 103 resp. EU A.2) in a quality controlled laboratory. The study is valid according to criteria mentioned in the test protocols.

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

method according to Siwoloboff

Boiling pt.:

248.8 °C

Atm. press.:

101.325 kPa

Decomposition:

no

Determination	Boiling Point	Atmospheric Pressure
1	242.1 °C (515.3 K)	100007 Pa
2	248.9 °C (522.1 K)	100444 Pa
3	247.9 °C (521.1 K)	100436 Pa

During heating, the yellowness of the sample became stronger.

The first and second determination showed a too high variation. Therefore, it was decided to perform a third determination. As the third determination confirmed the result of the second determination, determinations 2 and 3 were used for evaluation.

The boiling temperature at standard pressure can be calculated following the equation of Sidney-Young (only for small pressure deviations):

T_n= T + (f_T· Δp) 

with

Tn	boiling point [K] at 101.325 kPa
T	measured boiling point [K]
fT	rate of change of boiling temperature with pressure [K/kPa], i.e. a temperature-related correction factor
Δp	101.325 kPa – p [kPa]
p	measured atmospheric pressure [kPa]

The temperature-related correction factor (f_T) was calculated as 0.43 K/kPa for both boiling point values (521.1 K and 522.1 K) according to the equation f_T= 0.000843636 · T [K] – 0.008984727.

Corrected values according to Sidney-Young:

Determination	Boiling Point	Pressure	Corrected Boiling Point
2	248.9 °C (522.1 K)	100.444 kPa	249.3 °C (522.5 K)
3	247.9 °C (521.1 K)	100.436 kPa	248.3 °C (521.5 K)
mean			248.8 °C (522.0 K)

Mean ± standard deviation (after correction according to Sidney-Young): 248.8 ± 0.7 °C (522.0 ± 0.7 K).

Conclusions:

The boiling point of nicotine was determined by the Siwoloboff method and amounts to 248.8 ± 0.7 °C (522.0 ± 0.7 K). This value is the mean of two independent determinations, corrected to standard pressure.
No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.

Executive summary:

The boiling point of nicotine was determined by the Siwoloboff method and amounts to 248.8 ± 0.7 °C (522.0 ± 0.7 K). 

This value is corrected to standard pressure (101.325 kPa) with the Sidney-Young equation and corresponds to the mean of two independent determinations.

Description of key information

Study was conducted in a quality controlled laboratory. The results are reliable without restriction. Key study is appropriate for the risk assessment.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

248.8 °C