Nicotine

Flash point

Link to relevant study record(s)

Reference

Endpoint:

flash point of flammable liquids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014-09-22 to 2014-09-24

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: The study was performed in accordance with standard test protocols (EU A.9, OPPTS 830.6315, and UN Manual Test Methods 32.4) in a quality controlled laboratory. The study is valid according to criteria mentioned in the test protocols.

Qualifier:

according to guideline

Guideline:

EU Method A.9 (Flash-Point)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.6315 (Flammability)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

non-equilibrium method closed cup

Flash point:

111 °C

Atm. press.:

101.325 kPa

In a safety test, ca. 3 mL of the test item nicotine were heated in a test tube with a Bunsen burner to the boiling temperature (approximately 270 °C). Thereby, the light yellowish colour became stronger. After cooling down, no further changes of the test item were observed.

In the following pre-test and main study, about 70 mL of the liquid test item nicotine were used, respectively. Each determination was performed with a fresh aliquot of the test item.

The following program parameters were applied:

Determination	Heating Rate	Ignition Attempt
pre-test	8.5 °C/min	every 5 °C
main study	5.5 °C/min	every 2 °C, starting 22 °C below expected flash point

The following results were obtained:

Determination	Flash point [°C]	Mean [°C]	Notes
pre-test	115.5		not used for calculation
main study	111.5	111.0	difference < 2 °C
main study	110.5

Conclusions:

The flash point corresponds to the mean value of two determinations and amounts to 111.0 ± 0.5 °C (384.2 ± 0.5 K). The difference between the two measured values was below 2 °C. For this reason, the determination is considered valid.

Executive summary:

First, a safety test was performed: ca. 3 mL of the test item nicotine were heated to the boiling point of approximately 270 °C. Thereby, the light yellowish colour became more intensive, but no signs of polymerisation or decomposition were observed.

Then, a pre-test and a main study with two experiments were performed with a flash point tester.

The flash point of nicotine is stated as 111.0 ± 0.5 °C (384.2 ± 0.5 K).

This value is the mean of two independent determinations.

Description of key information

Study was conducted in a quality controlled laboratory. The results are reliable without restriction. Key study is appropriate for the risk assessment.

Key value for chemical safety assessment

Flash point at 101 325 Pa:

111 °C