Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-like

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
yes
Remarks:
Partition coefficient calculated on basis of solubility in water and solubility in octanol
GLP compliance:
no
Type of method:
other: Partition coefficient calculated on basis of solubility in water and solubility in octanol
Partition coefficient type:
octanol-water

Test material

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
<= -4.48
Temp.:
20 °C
Remarks on result:
other: pH only applicable for watery solutions

Applicant's summary and conclusion

Conclusions:
The log Pow was calculated according the equation
solubility of test item in n-octanol
Pow = -------------
solubility of test item in water
0,015 g/L
<= ---- <= 3,3 X 10-5
450 g/L

Log Pow <= -4,48