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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Reason / purpose for cross-reference:
read-across: supporting information
Qualifier:
according to guideline
Guideline:
other: ES-80-M-6
Principles of method if other than guideline:
Method is following the procedures described in the MIC Environmental Assessment Method for Conducting Acute Toxicity Tests with
Daphnia magna (Grueber and Adams, 1980) Environmental Sciences Report ES-80-M-6), and
Methods for Acute Toxicity Tests with fish, macroinvertebrates and amphibians (U.S. EPA (1975) EPA 660/3-75-009).
GLP compliance:
yes
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Duration:
48 h
Dose descriptor:
EC0
Effect conc.:
>= 640 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 640 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
RM-Freetext:
The original pH of the 640 mg/l stock solution was 3.01 and
afterwards raised with NaOH.
Executive summary:

A test on the acute toxicity to Daphnia magna was performed for phthalic acid according to "Methods for Acute Toxicity Tests" with fish, macroinvertebrates and amphibians of the US EPA. For a test period of 48 hours an EC50 value of > 640 mg/l was obtained (Adams, 1986).

Description of key information

A test with respect to the acute toxicity towards invertebrates (Daphnia magna) using the hydrolysis product phthalic acid as test substance is taken into account to describe the hazardous potential of phthalic anhydride towards aquatic invertebrates. An 48 h-EC50 of > 640 mg/l was determined in this test. (Adams, 1986)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
EC50
Effect concentration:
640 mg/L

Additional information

Concerning the toxicity with Daphnia magna there is only one test with phthalic anhydride available, but should not be used for the hazard assessment, due to missing information on pH. In comparison to the result found by Adams, 1986, where the hydrolysis product phthalic acid was used as test substance in a buffered medium, it cannot be excluded that the toxicity observed was due to pH effects. The study is stated to be reliable, but should not be used for the hazard assessment. In order to draw a conclusion on toxicity towards aquatic invertebrates for phthalic anhydride, the test on the acute toxicity to Daphnia magna with phthalic acid is taken into account. The study was performed according to “Methods for Acute Toxicity Tests” with fish, macroinvertebrates and amphibians of the US EPA. For a test period of 48 hours an EC50 value of > 640 mg/l was obtained (Adams, 1986).