Registration Dossier
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EC number: 242-362-4 | CAS number: 18479-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Acute oral and dermal toxicity studies with analogue chemicals indicating minimal toxicological effects.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 600 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
Oral Studies
In a key study, the acute oral LD50 value for the analogue chemical, dimyrcetol, was determined to be 4.1 g/kg bwt (3.5 to 4.8 g/kg bwt). In a second key study, the acute oral LD50 value for the analogue chemical, myrcenol, dihydro derivative, was 3.6 g/kg bwt (3.0 to 4.2 g/kg bwt). Signs of toxicity described included lethargy, piloerection, blood on the nose, flaccidity, ataxia, and diarrhea.
Dermal Study:
In a key study conducted for the Research Institute for Fragrance Materials, the acute dermal LD50 of dimyrcetol was determined to be > 5.0 g/kg bwt in rabbits. In a second key study, the acute dermal LD50 of myrcenol, dihydro derivative, was also determined to be > 5.0 g/kg bwt in rabbits. In these studies, there were 2/10 deaths recorded with clinical signs including moderate to severe erythema and mild to severe edema.
Inhalation Toxicity:
This requirement is waived based on the low vapor pressure of dihydromyrcenol, which precludes significant exposure by this route.
Please refer to Section 13 of this IUCLID file for read-across documentation and rationale for the selection of representative analogue chemicals.
Justification for classification or non-classification
Acute oral toxicity
Based on the acute toxicity of the analogue chemicals, dimyrcetol or myrcenol, dihydro derivative, dihydromyrcenol would not be rated for acute oral toxicity under either the EU DSD classification criteria (EU Directive 67/548/EEC) or under the EU CLP classification criteria (EU Regulation 1272/2008). Given the presence of apparent CNS depression in acute animal studies, dihydromyrcenol would be classified under the EU CLP classification criteria as STOT (single exposure) Category 3. Under the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN-GHS), dihydromyrcenol would be rated as Acute Toxicity, Category 5.
Inhalation toxicity
No information available for classification.
Dermal toxicity
Based on the results of acute dermal toxicity studies conducted in rabbits with the analogue chemicals, dimyrcetol or myrcenol, dihydro derivative, dihydromyrcenol would not be classified under the EU DSD classification criteria (EU Directive 67/548/EEC). Similarly, it would not receive classification under the EU CLP classification criteria (EU Regulation 1272/2008) or under the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN-GHS).
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